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Neurosci Biobehav Rev. 2018 Feb;85:93-101. doi: 10.1016/j.neubiorev.2017.05.011. Epub 2017 May 12.

High times for cannabis: Epigenetic imprint and its legacy on brain and behavior.

Author information

1
Friedman Brain Institute, Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
2
Friedman Brain Institute, Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Addiction Institute at Mount Sinai, New York, NY, USA. Electronic address: yasmin.hurd@mssm.edu.

Abstract

Extensive debates continue regarding marijuana (Cannabis spp), the most commonly used illicit substance in many countries worldwide. There has been an exponential increase of cannabis studies over the past two decades but the drug's long-term effects still lack in-depth scientific data. The epigenome is a critical molecular machinery with the capacity to maintain persistent alterations of gene expression and behaviors induced by cannabinoids that have been observed across the individual's lifespan and even into the subsequent generation. Though mechanistic investigations regarding the consequences of developmental cannabis exposure remain sparse, human and animal studies have begun to reveal specific epigenetic disruptions in the brain and the periphery. In this article, we focus attention on long-term disturbances in epigenetic regulation in relation to prenatal, adolescent and parental germline cannabinoid exposure. Expanding knowledge about the protracted molecular memory could help to identify novel targets to develop preventive strategies and treatments for behaviors relevant to neuropsychiatric risks associated with developmental cannabis exposure.

KEYWORDS:

Adolescence; Cannabinoid; Chromatin; DNA methylation; Epigenetics; Multigenerational inheritance; Prenatal development; Synaptic plasticity; Transcription

PMID:
28506926
PMCID:
PMC5682234
[Available on 2019-02-01]
DOI:
10.1016/j.neubiorev.2017.05.011

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