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Diagn Microbiol Infect Dis. 2017 Jul;88(3):268-270. doi: 10.1016/j.diagmicrobio.2017.04.013. Epub 2017 May 3.

First report of NDM-1-producing clinical isolate of Leclercia adecarboxylata in Spain.

Author information

1
Department of Microbiology, Virgen de las Nieves University Hospital-ibs, Granada, Spain. Electronic address: riazzoc@gmail.com.
2
Department of Microbiology, Virgen Macarena University Hospital, Seville, Spain.
3
Department of Microbiology, Virgen de las Nieves University Hospital-ibs, Granada, Spain.
4
Bacteriology-Hygiene unit, Assistance Publique/Hôpitaux de Paris (AP-PH), Bicêtre Hospital, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-producing Enterobacteriaceae, Le Kremlin-Bicêtre, France; EA7361 "Structure, dynamic, function and expression of broad spectrum β-lactamases", Université Paris-Sud, Université Paris-Saclay, LabEx LERMIT, Faculty of Medicine, Le Kremlin-Bicêtre, France.
5
Department of Preventive Medicine, Virgen de las Nieves University Hospital, Granada, Spain.
6
Bacteriology-Hygiene unit, Assistance Publique/Hôpitaux de Paris (AP-PH), Bicêtre Hospital, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-producing Enterobacteriaceae, Le Kremlin-Bicêtre, France; EA7361 "Structure, dynamic, function and expression of broad spectrum β-lactamases", Université Paris-Sud, Université Paris-Saclay, LabEx LERMIT, Faculty of Medicine, Le Kremlin-Bicêtre, France; Joint Research Unit EERA «Evolution and Ecology of Resistance to Antibiotics», Institut Pasteur - APHP - Université Paris Sud, Paris, France.

Abstract

We describe the case of NDM-1-producing Leclercia adecarboxylata recovered from the clinical sample of a patient hospitalized for a trauma-related injury to his foot. The isolate was resistant to all beta-lactams, quinolones, trimetroprim-sulfametoxazol, gentamicin and tobramicyn. The blaNDM-1 gene was located in a conjugative plasmid that also contained the blaSHV-12 gene and was preceded by a disrupted insertion sequence of ISAba125. The plasmid belongs to the incompatibility group X3, which is known to be an important vector for NDM-1 dissemination in China. This is the first reported case of NDM-1L. adecarboxylata in our country and evidences that species of uncertain clinical relevance can act as hidden sources of clinically important resistance determinants.

KEYWORDS:

China; Inc.-X3; L. adecarboxilata; NDM-1; Spain

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