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Clin Nutr. 2017 Dec;36(6):1530-1539. doi: 10.1016/j.clnu.2017.04.021. Epub 2017 May 4.

Effects of continuous use of probiotics before liver transplantation: A randomized, double-blind, placebo-controlled trial.

Author information

1
Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland. Electronic address: michal.grat@gmail.com.
2
Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
3
Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland.
4
Second Department of Clinical Radiology, Medical University of Warsaw, Warsaw, Poland.
5
Department of Preventive Medicine and Hygiene, Medical University of Warsaw, Warsaw, Poland.
6
Hepatology and Internal Medicine Unit, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.

Abstract

BACKGROUND & AIMS:

Although there is increasing evidence for the benefits of probiotics in patients with liver diseases, data on the benefits of pre-LT administration of probiotics are lacking. The aim of this study was to evaluate the effects of continuous administration of probiotics before liver transplantation (LT) on pre- and post-transplant patient outcomes.

METHODS:

In this randomized, double-blind, and placebo-controlled trial adult cirrhotic patients listed for LT received a 4-strain probiotic preparation or placebo daily from enrollment until LT. The primary outcome measures were postoperative mortality and infection rates. The secondary outcome measures were 5-day post-transplant aspartate and alanine aminotransferase activities, bilirubin concentration, and international normalized ratio; waiting-list mortality; pre-transplant Model for End-stage Liver Disease score and Child-Turcotte-Pugh class changes; and pre-transplant infections.

RESULTS:

A total of 55 patients were randomized. The 90-day postoperative mortality rates were 0% and 4.3% in the probiotic and placebo groups, respectively (p > 0.99). Patients receiving probiotics had significantly reduced 30-day (4.8% versus 34.8%, p = 0.02) and 90-day (4.8% versus 47.8%, p = 0.002) infection rates, lower post-LT bilirubin concentration (p = 0.02), and more rapid decrease of aspartate (p = 0.03) and alanine (p = 0.03) aminotransferase activities. Probiotics did not have significant effects on other secondary outcome measures.

CONCLUSIONS:

Although continuous administration of probiotics before LT does not appear to affect postoperative mortality, it effectively prevents postoperative infections and improves early biochemical parameters of allograft function. CLINICALTRIALS.

GOV IDENTIFIER:

NCT01735591.

KEYWORDS:

Allograft function; Liver transplantation; Nutrition; Postoperative infections; Probiotics

PMID:
28506447
DOI:
10.1016/j.clnu.2017.04.021
[Indexed for MEDLINE]

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