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Gastroenterol Clin North Am. 2017 Jun;46(2):273-296. doi: 10.1016/j.gtc.2017.01.004.

Drug-induced Liver Injury: The Hepatic Pathologist's Approach.

Author information

1
Laboratory of Pathology, National Cancer Institute, 10 Center Drive, Building 10, Room 2S235, MSC 1500, Bethesda, MD 20892, USA. Electronic address: kleinerd@mail.nih.gov.

Abstract

The evaluation of liver biopsies in suspected drug-induced liver injury (DILI) can be complex. The biopsy may be approached systematically, by identification of histologic lesions and then identification of the overall pattern of injury. Potential DILI must be separated from concomitant non-DILI liver disease. The findings can be analyzed with respect to the various prescription and nonprescription medications and dietary supplements under suspicion to provide a complete interpretation of the findings. The pathologic findings, the histologic differential diagnosis, and expert interpretation are part of a complete biopsy assessment and provide information that is of greatest value in patient management.

KEYWORDS:

Acute hepatitis; Acute liver failure; Cholestasis; Hepatic necrosis; Hepatotoxicity

PMID:
28506365
PMCID:
PMC5434713
DOI:
10.1016/j.gtc.2017.01.004
[Indexed for MEDLINE]
Free PMC Article

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