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Cardiovasc Res. 2017 Jul 1;113(9):1024-1034. doi: 10.1093/cvr/cvx098.

MicroRNAs in dysfunctional adipose tissue: cardiovascular implications.

Author information

1
Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB-742F, Boston, MA 02115, USA.

Abstract

In this review, we focus on the emerging role of microRNAs, non-coding RNAs that regulate gene expression and signaling pathways, in dysfunctional adipose tissue. We highlight current paradigms of microRNAs involved in adipose differentiation and function in depots such as white, brown, and beige adipose tissues and potential implications of microRNA dysregulation in human disease such as obesity, inflammation, microvasculature dysfunction, and related cardiovascular diseases. We highlight accumulating studies indicating that adipocyte-derived microRNAs may not only serve as biomarkers of cardiometabolic disease, but also may directly regulate gene expression of other tissues. Finally, we discuss the future prospects, challenges, and emerging strategies for microRNA delivery and targeting for therapeutic applications in cardiovascular disease states associated with adipocyte dysfunction.

KEYWORDS:

Adipocytes; Brown adipose tissue; MicroRNA; White adipose tissue

PMID:
28505257
PMCID:
PMC5852642
DOI:
10.1093/cvr/cvx098
[Indexed for MEDLINE]
Free PMC Article

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