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Pediatr Transplant. 2017 Aug;21(5). doi: 10.1111/petr.12937. Epub 2017 May 14.

Sudden death in a pediatric heart transplant recipient with peripheral eosinophilia and eosinophilic myocardial infiltrates.

Author information

1
Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
2
Division of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
3
Department of Pediatrics, Labatt Family Heart Centre, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
4
University of Alberta, Stollery Children's Hospital, Edmonton, AB, Canada.
5
Division of Pathology, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
6
Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Abstract

Eosinophilia has been rarely reported in pediatric heart transplant recipients and has been suggested to play a role in graft rejection. We report a case of a young female patient with peripheral blood eosinophilia who died suddenly 2 years following ABO-incompatible heart transplantation. She was found at autopsy to have myocardial infiltration of not only T-lymphocytes and macrophages expected in acute cellular rejection but also of eosinophils, B-lymphocytes, and plasma cells indicating myocarditis.

KEYWORDS:

ABO-incompatible; eosinophilia; myocarditis; pediatric heart transplant; transplant rejection

PMID:
28504342
DOI:
10.1111/petr.12937
[Indexed for MEDLINE]

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