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J Vet Intern Med. 2017 Jul;31(4):1159-1162. doi: 10.1111/jvim.14724. Epub 2017 May 15.

Evaluation of Weight Change During Carboplatin Therapy in Dogs With Appendicular Osteosarcoma.

Author information

1
College of Veterinary Medicine, University of Florida, Gainesville, FL.
2
Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
3
University of California-Davis School of Veterinary Medicine, Davis, CA.
4
College of Public Health and Health Professions, University of Florida, Gainesville, FL.

Abstract

BACKGROUND:

The prevalence of cancer cachexia in veterinary medicine has not been studied widely, and as of yet, no definitive diagnostic criteria effectively assess this syndrome in veterinary patients.

OBJECTIVES:

(1) To determine the patterns of weight change in dogs with appendicular osteosarcoma treated with amputation and single-agent carboplatin during the course of adjuvant chemotherapy; and (2) to determine whether postoperative weight change is a negative prognostic indicator for survival time in dogs with osteosarcoma.

ANIMALS:

Eighty-eight dogs diagnosed with appendicular osteosarcoma. Animals were accrued from 3 veterinary teaching hospitals.

METHODS:

Retrospective, multi-institutional study. Dogs diagnosed with appendicular osteosarcoma and treated with limb amputation followed by a minimum of 4 doses of single-agent carboplatin were included. Data analyzed in each patient included signalment, tumor site, preoperative serum alkaline phosphatase activity (ALP), and body weight (kg) at each carboplatin treatment.

RESULTS:

A slight increase in weight occurred over the course of chemotherapy, but this change was not statistically significant. Weight change did not have a significant effect on survival. Institution, patient sex, and serum ALP activity did not have a significant effect on survival.

CONCLUSIONS AND CLINICAL IMPORTANCE:

Weight change was not a prognostic factor in these dogs, and weight loss alone may not be a suitable method of determining cancer cachexia in dogs with appendicular osteosarcoma.

KEYWORDS:

Cachexia; Canine; Chemotherapy; Oncology

PMID:
28503759
PMCID:
PMC5508317
DOI:
10.1111/jvim.14724
[Indexed for MEDLINE]
Free PMC Article

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