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Qual Life Res. 2017 Sep;26(9):2459-2469. doi: 10.1007/s11136-017-1595-4. Epub 2017 May 13.

Depression severity and concentration difficulties are independently associated with HRQOL in patients with unipolar depressive disorders.

Author information

1
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. alice.fattori@gmail.com.
2
Outcomes Research Consulting, Milan, Italy.
3
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
4
Department of Mental Health, ASL3, Genoa, Italy.
5
Depression Unit, Neuroscience Department, Fatebenefratelli Hospital, Milan, Italy.

Abstract

PURPOSE:

Cognitive impairment is a core feature of major depressive disorder (MDD), and dysfunctions in this area strongly contribute to MDD-associated disability. Whether cognitive impairment has an independent clinical course and a unique impact on HRQOL is still debated. We sought to characterize the relationship between depression severity and HRQOL, evaluating the burden of concentration difficulties on HRQOL.

METHODS:

Six hundred ninety-two patients with unipolar depressive disorders recruited in 19 Italian centers answered a self-administered survey (SF-12 questionnaire, socio-demographic information). A psychiatrist completed a standardized data collection form encompassing a depression severity scale (MADRS) and clinical information.

RESULTS:

There was a strong graded association between the severity of depressive symptoms and both the physical (ω 2 = 0.13; p < 0.01) and mental (ω 2 = 0.34; p < 0.01) SF-12 domains. Additionally, we observed a strong association between concentration difficulties and all HRQOL outcomes independent of other symptoms of depression and robust to adjustment for possible confounders.

CONCLUSIONS:

Our data corroborate previous findings suggesting that cognitive impairment is a feature of unipolar depressive disorders partially independent of the severity of other symptoms, and may represent a specific target of therapy with a strong impact on patients' functioning and quality of life.

KEYWORDS:

Cognitive impairment; Depression severity; HRQoL; MADRS; SF-12; Unipolar depressive disorder

PMID:
28503714
DOI:
10.1007/s11136-017-1595-4
[Indexed for MEDLINE]

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