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Semin Cancer Biol. 2017 Dec;47:1-17. doi: 10.1016/j.semcancer.2017.05.004. Epub 2017 May 11.

Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.

Author information

1
Department of Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
2
Department of Biology, Merrimack College, North Andover, MA, USA.
3
Department of Genetics, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Environmental Health, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Aging, University of Alabama at Birmingham, Birmingham, AL, USA; UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA; Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA. Electronic address: kksingh@uab.edu.

Abstract

Mitochondria are complex intracellular organelles that have long been identified as the powerhouses of eukaryotic cells because of the central role they play in oxidative metabolism. A resurgence of interest in the study of mitochondria during the past decade has revealed that mitochondria also play key roles in cell signaling, proliferation, cell metabolism and cell death, and that genetic and/or metabolic alterations in mitochondria contribute to a number of diseases, including cancer. Mitochondria have been identified as signaling organelles, capable of mediating bidirectional intracellular information transfer: anterograde (from nucleus to mitochondria) and retrograde (from mitochondria to nucleus). More recently, evidence is now building that the role of mitochondria extends to intercellular communication as well, and that the mitochondrial genome (mtDNA) and even whole mitochondria are indeed mobile and can mediate information transfer between cells. We define this promiscuous information transfer function of mitochondria and mtDNA as "momiome" to include all mobile functions of mitochondria and the mitochondrial genome. Herein, we review the "momiome" and explore its role in cancer development, progression, and treatment.

KEYWORDS:

Anterograde; Cancer; Cancer prevention; Epigenetic; Exosome; Extracellular ATP; Intercellular; Mipigenetics; Mitochondria; Mitochondria-to-nucleus; Mitochondrial DNA; Nuclear mitochondria; Nucleus-to-mitochondria; Numtogenesis; Retrograde; Therapy; miRNA

PMID:
28502611
PMCID:
PMC5681893
DOI:
10.1016/j.semcancer.2017.05.004
[Indexed for MEDLINE]
Free PMC Article

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