Differences in the imaging features and distribution of non-indolent and indolent mastocytosis: a single institution experience of 29 patients

Clin Imaging. 2017 Jul-Aug:44:111-116. doi: 10.1016/j.clinimag.2017.05.003. Epub 2017 May 6.

Abstract

Purpose: Compare imaging features of indolent and non-indolent mastocytosis.

Methods: For 29 patients, imaging features, imaging indications, and distribution of indolent and non-indolent mastocytosis subtypes were analyzed.

Results: 16/29 (55%) patients had three distinct patterns of osseous abnormality, not significantly differing between cohorts. Non-indolent disease was more likely to present with hepatomegaly (p=0.0004), splenomegaly (p=0.0097), and lymphadenopathy (p=0.0079). CT, was the most common initial imaging modality, ordered to stage disease in 20 of 29 patients (69%).

Conclusion: Understanding patterns of involvement of indolent and nonindolent mastocytosis across modalities could assist radiologists in evaluating mastocytosis.

Keywords: Imaging; Indolent; Mastocytosis; Non-indolent.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Bone and Bones / pathology
  • Female
  • Hepatomegaly / pathology
  • Humans
  • Lymphadenopathy / pathology
  • Male
  • Mastocytosis / diagnostic imaging*
  • Middle Aged
  • Splenomegaly / pathology
  • Tomography, X-Ray Computed / methods*