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J Hosp Infect. 2017 Aug;96(4):349-352. doi: 10.1016/j.jhin.2017.05.004. Epub 2017 May 10.

Comparative effectiveness of faecal microbiota transplant by route of administration.

Author information

1
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: ngundacker@uabmc.edu.
2
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
3
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
4
Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

Abstract

The optimal route of delivery for faecal microbiota transplant (FMT) is unknown. This observational single-centre study analysed the two-week cure rates for all patients who received FMT from 2013 to 2016 according to route of delivery. Overall, nasogastric delivery of FMT was less effective than lower endoscopic delivery. When patients were stratified by illness severity, nasogastric delivery achieved similar cure rates in healthier individuals, whereas lower endoscopic delivery was preferred for relatively ill individuals. Nasogastric delivery may be less effective than lower endoscopic delivery; however, when taking the cost, preparation and potential risk into account, this difference may not be clinically significant for patients with mild disease.

KEYWORDS:

Clostridium difficile; Colonoscopy; Faecal microbiota transplant; Nasogastric

PMID:
28501333
DOI:
10.1016/j.jhin.2017.05.004
[Indexed for MEDLINE]

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