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Environ Pollut. 2017 Sep;228:1-7. doi: 10.1016/j.envpol.2017.05.013. Epub 2017 May 10.

The influence of polycyclic aromatic hydrocarbons on lung function in a representative sample of the Canadian population.

Author information

1
Population Studies Division, Health Canada, Ottawa, ON K1A 0K9, Canada. Electronic address: sabit.cakmak@canada.ca.
2
Population Studies Division, Health Canada, Ottawa, ON K1A 0K9, Canada.
3
Department of Biomedical Science, University of Ottawa, Ottawa, ON Canada.

Abstract

We investigated the associations between exposure to polycyclic aromatic hydrocarbons (PAHs) and selected respiratory physiologic measures in cycles 2 and 3 of the Canadian Health Measures Survey, a nationally representative population sample. Using generalized linear mixed models, we tested the association between selected PAH metabolites and 1-second forced expiratory volume (FEV1), forced vital capacity (FVC), and the ratio between the two (FEV1/FVC) in 3531 people from 6 to 79 years of age. An interquartile change in urinary PAH metabolite was associated with significant decrements in FEV1 and FVC for eight PAHs, 2-hydroxynapthalene, 1-, and 2-hydroxyphenanthrene, 2-, 3-, and 9-hydroxyfluorene and 3- and 4-hydroxyphenanthrene. Exposure to PAH may negatively affect lung function in the Canadian population.

KEYWORDS:

Epidemiology; Lung function; Polycyclic aromatic hydrocarbons; Population health

PMID:
28500931
DOI:
10.1016/j.envpol.2017.05.013
[Indexed for MEDLINE]
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