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Brain Res. 1988 Nov 8;473(1):187-92.

Voltage-clamp analysis of a transient potassium current in rat neostriatal neurons.

Author information

1
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163.

Abstract

Whole cell voltage-clamp recordings were made from cultured rat neostriatal neurons. Depolarizing voltage commands evoked transient and sustained outward K-currents. The transient K-current was activated by depolarizing commands beyond -50 mV; peak current was dependent upon holding potential. Bath application of 4-aminopyridine, but not inorganic calcium channel blockers (Cd, Co, Mn), attenuated the transient current. Reversal was near the K-equilibrium potential. These properties suggest that this transient K-current is similar to the A-current described in a number of other neurons.

PMID:
2850087
DOI:
10.1016/0006-8993(88)90334-4
[Indexed for MEDLINE]

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