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J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1492-1500. doi: 10.1093/gerona/glx090.

The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.

Author information

1
Feinberg School of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois.
2
Division of Aging Biology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
3
Division of Lung Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
4
Center for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.
5
Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois.
6
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
7
Departments of Epidemiology, Laboratory Medicine & Pathology, Brown University, Providence, Rhode Island.
8
Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan, México.
9
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver Health Sciences Center, Denver, Colorado.
10
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York.
11
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
12
Department of Surgery, University of Colorado at Denver Health Sciences Center, Denver, Colorado.
13
University of Alabama at Birmingham, Birmingham, Alabama.
14
Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
15
Weill Cornell Medical College, Division of Pulmonary and Critical Care Medicine, Weill Department of Medicine, New York, New York.
16
Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus.
17
Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, California.
18
Respiratory Institute, Hospital Clinic, IDIBAPS, University of Barcelona, CIBERES, Spain.
19
Department of Chemical Physiology, Department of Cell and Molecular Biology, The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California.
20
Division of Clinical Immunology, Department of Medicine, Mount Sinai School of Medicine, New York, New York.
21
Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois.
22
Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois.

Abstract

Death from chronic lung disease is increasing and chronic obstructive pulmonary disease has become the third leading cause of death in the United States in the past decade. Both chronic and acute lung diseases disproportionately affect elderly individuals, making it likely that these diseases will become more frequent and severe as the worldwide population ages. Chronic lung diseases are associated with substantial morbidity, frequently resulting in exercise limiting dyspnea, immobilization, and isolation. Therefore, effective strategies to prevent or treat lung disease are likely to increase healthspan as well as life span. This review summarizes the findings of a joint workshop sponsored by the NIA and NHLBI that brought together investigators focused on aging and lung biology. These investigators encouraged the use of genetic systems and aged animals in the study of lung disease and the development of integrative systems-based platforms that can dynamically incorporate data sets that describe the genomics, transcriptomics, epigenomics, metabolomics, and proteomics of the aging lung in health and disease. Further research was recommended to integrate benchmark biological hallmarks of aging in the lung with the pathobiology of acute and chronic lung diseases with divergent pathologies for which advanced age is the most important risk factor.

KEYWORDS:

Age-related pathology; Biology of aging; Lungs/pulmonary

PMID:
28498894
PMCID:
PMC5861849
DOI:
10.1093/gerona/glx090
[Indexed for MEDLINE]
Free PMC Article

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