Format

Send to

Choose Destination
J Gastroenterol Hepatol. 2018 Jan;33(1):150-155. doi: 10.1111/jgh.13821.

Asia-Pacific Colorectal Screening score: A useful tool to stratify risk for colorectal advanced neoplasms in Vietnamese patients with irritable bowel syndrome.

Author information

1
Department of Internal Medicine, University of Medicine and Pharmacy, Hochiminh, Vietnam.
2
Department of Gastroenterology, Gia-Dinh People's Hospital, Hochiminh, Vietnam.
3
Health Service Center, Hiroshima University, Higashihiroshima, Japan.
4
Department of Gastroenterology, Trung-Vuong Hospital, Hochiminh, Vietnam.
5
Department of Gastroenterology, Can-Tho City General Hospital, Can-Tho, Vietnam.
6
Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.

Abstract

BACKGROUND AND AIM:

The Asia-Pacific Colorectal Screening (APCS) score has been validated in several populations but not yet in patients with irritable bowel syndrome (IBS). The aim of this study was to assess the performance of APCS score in stratifying risk of colorectal advanced neoplasms (CAN) in Vietnamese IBS patients.

METHODS:

Consecutive patients who fulfilled IBS diagnosis criteria according to the Rome III were prospectively enrolled and underwent colonoscopy. APCS score for each patient was calculated by summing the points attributed by risk factors. Three tiers of risk were defined: 0-1 "average risk" (AR); 2-3 "moderate risk" (MR); and 4-7 "high risk" (HR). Logistic regression analysis was performed to assess the relative risk of CAN in HR group and MR group compared with AR group.

RESULTS:

There were 404 patients with excellent bowel preparation and complete colonoscopy. The mean age was 48.8 ± 11.2 years and male : female ratio was 1.2:1. Twenty-eight patients (6.9%) were diagnosed with CAN: 19 (4.7%) advanced adenoma and 9 (2.2%) invasive colorectal cancer. Patients in the MR and HR tiers had 5.6-fold (95% confidence interval 1.2 to 24.7, P = 0.012) and 12.1-fold (95% confidence interval 2.6 to 56.2, P < 0.001) increased rates of CAN compared with those in the AR tier, respectively. Three out of 9 patients with invasive colorectal cancer had no alarm features but had high sum APCS score (2 in MR tier and 1 in HR tier).

CONCLUSION:

The APCS score is useful to identify IBS patients with high risk of CAN for colonoscopy priority.

KEYWORDS:

Vietnamese; colon cancer; early detection; irritable bowel syndrome; risk

PMID:
28497589
DOI:
10.1111/jgh.13821
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center