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Contact Dermatitis. 2017 Jul;77(1):1-16. doi: 10.1111/cod.12789. Epub 2017 May 12.

Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis.

Author information

1
Department of Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
2
Department of Dermatology-Allergology, VU University Medical Centre, 081 HV, Amsterdam, The Netherlands.
3
Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
4
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, 2400, Copenhagen, Denmark.
5
Department of Dermatology, University of Lübeck, 23538, Lübeck, Germany.
6
Institute of Clinical Medicine, University of Oslo, 0318, Oslo, Norway.
7
Department of Dermatology, Oslo University Hospital, 0424, Oslo, Norway.
8
Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, 20246, Hamburg, Germany.
9
Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, 49076, Osnabrück, Germany.
10
Department of Pharmacology and Toxicology, University of Lausanne, 1011, Lausanne, Switzerland.
11
Faculty of Food Technology and Biotechnology, Department of Chemistry and Biochemistry, Laboratory for Analytical Chemistry, University of Zagreb, 10000, Zagreb, Croatia.
12
University Department of Dermatovenereology, Clinical Hospital Zagreb and School of Medicine, 10000, Zagreb, Croatia.
13
Department of Pathology, Oslo University Hospital - Rikshospitalet, 0424, Oslo, Norway.
14
Centre for Immune Regulation, University of Oslo, 0424, Oslo, Norway.
15
Department of Dermatology and Allergology, Ludwig-Maximilians-University, 81377, München, Germany.
16
Department of Dermatology, Finnish Institute of Occupational Health, 00251, Helsinki, Finland.
17
Department of Chemicals and Product Safety, German Federal Institute for Risk Assessment, 10589, Berlin, Germany.
18
Laboratory for Immunology & Proteomics, Department of Dermatology and University Medical Centre Mannheim, University of Heidelberg, 68167, Mannheim, Germany.
19
Department of Dermatology, Allergy Research Group, Medical Centre - University of Freiburg, 79104, Freiburg, Germany.

Abstract

Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.

KEYWORDS:

allergic contact dermatitis; biomarkers; contact allergy; contact sensitization

PMID:
28497472
DOI:
10.1111/cod.12789
[Indexed for MEDLINE]
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