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AAPS J. 2017 Jul;19(4):1029-1044. doi: 10.1208/s12248-017-0072-x. Epub 2017 May 11.

Controlled Ion Release from Novel Polyester/Ceramic Composites Enhances Osteoinductivity.

Author information

1
Department of Chemical Engineering, University of Missouri, W2027 Lafferre Hall, 416 S. 6th Street, Columbia, Missouri, 65211, USA.
2
Department of Chemical Engineering, University of Missouri, W2027 Lafferre Hall, 416 S. 6th Street, Columbia, Missouri, 65211, USA. TataR@missouri.edu.
3
Department of Bioengineering, University of Missouri, Columbia, Missouri, 65211, USA.
4
Department of Chemistry, University of Missouri, Columbia, Missouri, 65211, USA.
5
Department of Chemical Engineering, University of Missouri, W2027 Lafferre Hall, 416 S. 6th Street, Columbia, Missouri, 65211, USA. uleryb@missouri.edu.
6
Department of Bioengineering, University of Missouri, Columbia, Missouri, 65211, USA. uleryb@missouri.edu.

Abstract

Due to the growing number of patients suffering from musculoskeletal defects and the limited supply of and sub-optimal outcomes associated with biological graft materials, novel biomaterials must be created that can function as graft substitutes. For bone regeneration, composite materials that mimic the organic and inorganic phases of natural bone can provide cues which expedite and enhance endogenous repair. Specifically, recent research has shown that calcium and phosphate ions are inherently osteoinductive, so controllably delivering their release holds significant promise for this field. In this study, unique aliphatic polyesters were synthesized and complexed with a rapidly decomposing ceramic (monobasic calcium phosphate, MCP) yielding novel polymer/ceramic composite biomaterials. It was discovered that the fast dissolution and rapid burst release of ions from MCP could be modulated depending on polymer length and chemistry. Also, controlled ion release was found to moderate solution pH associated with polyester degradation. When composite biomaterials were incubated with mesenchymal stems cells (MSCs) they were found to better facilitate osteogenic differentiation than the individual components as evidenced by increased alkaline phosphate expression and more rapid mineralization. These results indicate that controlling calcium and phosphate ion release via a polyester matrix is a promising approach for bone regenerative engineering.

KEYWORDS:

calcium/phosphate ions; mesenchymal stem cells; monobasic calcium phosphate; osteoinduction; polyesters

PMID:
28497318
DOI:
10.1208/s12248-017-0072-x
[Indexed for MEDLINE]

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