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J Renal Inj Prev. 2017 Jan 20;6(2):153-157. doi: 10.15171/jrip.2017.30. eCollection 2017.

An update on diabetic kidney disease, oxidative stress and antioxidant agents.

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Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
School of Nutrition & Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.


Diabetes mellitus is a metabolic disease that is defined by relative or absolute deficiency of insulin secretion. Diabetic kidney disease seems to be one of the most frequent complications of diabetes mellitus. Based on evidence, increased free-radical formation and/or diminished antioxidant defenses induce oxidative stress that is implicated in the pathogenesis of diabetic kidney disease. It is evident that diabetic state induces oxidative stress through different signaling pathways as well as reactive oxygen species (ROS) formation that attributes to the activation of various downstream signaling cascade leading to structural the way to structural and functional changes in kidney.


Antioxidant; Diabetes mellitus; Kidney disease; Oxidative stress

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