Send to

Choose Destination
Front Neural Circuits. 2017 Apr 27;11:31. doi: 10.3389/fncir.2017.00031. eCollection 2017.

Monitoring the Right Collection: The Central Cholinergic Neurons as an Instructive Example.

Author information

Lendület Laboratory of Systems Neuroscience, Department of Cellular and Network Neurobiology, Institute of Experimental Medicine - Hungarian Academy of SciencesBudapest, Hungary.
János Szentágothai Doctoral School of Neurosciences, Semmelweis UniversityBudapest, Hungary.


Some neurons are more equal than others: neuroscience relies heavily on the notion that there is a division of labor among different subtypes of brain cells. Therefore, it is important to recognize groups of neurons that participate in the same computation or share similar tasks. However, what the best ways are to identify such collections is not yet clear. Here, we argue that monitoring the activity of genetically defined cell types will lead to new insights about neural mechanisms and improve our understanding of disease vulnerability. Through highlighting how central cholinergic neurons encode reward and punishment that can be captured by a unified framework of reinforcement surprise, we hope to provide an instructive example of how studying a genetically defined cell type may further our understanding of neural function.


Alzheimer’s disease; cell types; cholinergic; connectivity; optogenetics

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center