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Sci Rep. 2017 May 11;7(1):1719. doi: 10.1038/s41598-017-01193-6.

Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer's disease and FDG-PET findings.

Hsu JL1,2,3,4, Hsu WC4, Chang CC5, Lin KJ6,7, Hsiao IT6,7, Fan YC8, Bai CH9,10.

Author information

1
Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang-Gung University, Taoyuan, Taiwan.
2
Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan.
3
Brain and Consciousness Research Center, Taipei Medical University, Taipei, Taiwan.
4
Dementia Center and Section of Dementia, Department of Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
5
Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
6
Department of Nuclear Medicine and Center for Advanced Molecular Imaging and Translation, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
7
Department of Medical Imaging and Radiological Sciences and Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
8
School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan. elvics@gmail.com.
9
School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan. baich@tmu.edu.tw.
10
Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan. baich@tmu.edu.tw.

Abstract

We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer's disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total of 160 normal aging adults and 40 patients with the early stage of probable AD were included. Neuropsychological performance was assessed using the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB). 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans were used to measure AD-related hypometabolism. Nonparametric Spearman correlation analysis was used to study associations between ECog and z-transformed total CERAD-NAB scores in both groups. The results revealed a significant correlation between total ECog and CERAD-NAB scores (rho = -0.28, p < 0.01), and category verbal fluency test with the executive domain of the ECog scale (rho = -0.20, p < 0.01). The CERAD-NAB scores were also significantly correlated with AD-related hypometabolism (rho = -0.49, p < 0.01). The memory domain of the ECog scale was significantly correlated with FDG uptake in the angular gyrus and posterior cingulum gyrus (rho = -0.41 and -0.46, P < 0.01). In conclusion, both total and memory domain ECog scores were correlated with the neuropsychological tests and neuroimaging biomarkers.

PMID:
28496183
PMCID:
PMC5431919
DOI:
10.1038/s41598-017-01193-6
[Indexed for MEDLINE]
Free PMC Article

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