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Sci Rep. 2017 May 11;7(1):1723. doi: 10.1038/s41598-017-01827-9.

Exploring the link between cadmium and psoriasis in a nationally representative sample.

Author information

1
Family Medicine and Geriatric Medicine, Department of Family and Community health, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
2
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
3
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
4
Department of Dermatology, Taoyuan Armed Forces General Hospital, Taoyuan and National Defense Medical Center, Taipei, Taiwan. lamoneparrot@hotmail.com.

Abstract

Psoriasis, a skin inflammatory disease, originates from dysregulated interactions of the immune system. Cadmium, an environment pollutant, increases the levels of inflammation markers and influences the immune system. To clarify the relationship between cadmium and psoriasis, 5,927 participants, ≥20 years, in the National Health and Nutrition Examination Survey (NHANES) 2003-2006 were studied. Psoriasis severity was assessed using self-reported dermatology questionnaires. Cadmium was measured using blood chemistry. Three adjusted models were applied for the interaction between serum cadmium and severity of psoriasis. Psoriasis patients had significantly higher blood cadmium (0.67 vs. 0.52 μg/L, p = 0.006). There was a strong linear increase in predicted blood cadmium values with an increase in severity of psoriasis (p for trend = 0.002). The β coefficient of the predicted serum cadmium in the "few patches to extensive psoriasis" group was 0.234 (p = 0.002) after adjusting covariates. Participants with severe psoriasis have higher blood cadmium. Environmental exposure to cadmium can predispose to the worsening of psoriasis. Although there are still limitations in this study, such as not included treatment data, these results have substantial public health implications for the general population, as they demonstrate the importance of cadmium exposure prevention, particularly among psoriasis patients.

PMID:
28496169
PMCID:
PMC5431928
DOI:
10.1038/s41598-017-01827-9
[Indexed for MEDLINE]
Free PMC Article

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