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Trends Cogn Sci. 2017 Jul;21(7):531-545. doi: 10.1016/j.tics.2017.04.006. Epub 2017 May 8.

An Update on Memory Reconsolidation Updating.

Author information

1
School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: j.l.c.lee@bham.ac.uk.
2
Department of Psychology, McGill University, Department of Psychology,1205 Dr Penfield Avenue, Montreal, QC H3A 1B1, Canada. Electronic address: karim.nader@mcgill.ca.
3
Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai and Friedman Brain Institute, New York, NY 10029, USA. Electronic address: daniela.schiller@mssm.edu.

Abstract

The reactivation of a stored memory in the brain can make the memory transiently labile. During the time it takes for the memory to restabilize (reconsolidate) the memory can either be reduced by an amnesic agent or enhanced by memory enhancers. The change in memory expression is related to changes in the brain correlates of long-term memory. Many have suggested that such retrieval-induced plasticity is ideally placed to enable memories to be updated with new information. This hypothesis has been tested experimentally, with a translational perspective, by attempts to update maladaptive memories to reduce their problematic impact. We review here progress on reconsolidation updating studies, highlighting their translational exploitation and addressing recent challenges to the reconsolidation field.

KEYWORDS:

addiction; counterconditioning; extinction; memory; reconsolidation; retrieval

PMID:
28495311
PMCID:
PMC5605913
DOI:
10.1016/j.tics.2017.04.006
[Indexed for MEDLINE]
Free PMC Article

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