Isolation and structure elucidation of a new compound from the fungus Aspergillus flavipes PJ03-11

Fang Liu; Gang Chen; Li-Hua Zhang; Bing Liu; Shaofei Chen; Huiming Hua; Jiao Bai; Hai-Feng Wang; Yue-Hu Pei

doi:10.1080/14786419.2017.1326490

Isolation and structure elucidation of a new compound from the fungus Aspergillus flavipes PJ03-11

Nat Prod Res. 2018 Jan;32(1):30-35. doi: 10.1080/14786419.2017.1326490. Epub 2017 May 11.

Authors

Fang Liu^{1

2}, Gang Chen^{1

2}, Li-Hua Zhang^{1

3}, Bing Liu^{1

4}, Shaofei Chen^{1

2}, Huiming Hua^{1

2}, Jiao Bai^{1

2}, Hai-Feng Wang^{1

2}, Yue-Hu Pei^{1

2}

Affiliations

¹ a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , China.
² b Key Laboratory of Structure-Based Drug Design and Discovery , Shenyang Pharmaceutical University, Ministry of Education , Shenyang , China.
³ c Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China.
⁴ d Life science and Environmental Science Research Center , Harbin University of Commerce , Harbin , China.

PMID: 28494651
DOI: 10.1080/14786419.2017.1326490

Abstract

A new diphenyl ether 3-methylpentyl-2, 4-dichloroasterrate (2), along with a known diphenyl ether butyl 2, 4-dichloroasterrate (1) were isolated from the metabolites of a wetland fungus Aspergillus flavipes. PJ03-11. The structures of 1 and 2 were determined by extensive NMR and HR-ESI-MS experiments. Compounds 1 and 2 showed weak cytotoxic activity, but both of them showed no antimicrobial activity.

Keywords: Aspergillus; Soil fungus; cytotoxic activity; diphenyl ether.

MeSH terms

Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Aspergillus / chemistry*
Crystallography, X-Ray
Drug Evaluation, Preclinical / methods
HL-60 Cells
Humans
Hydroxybenzoates / chemistry
Hydroxybenzoates / pharmacology*
Magnetic Resonance Spectroscopy
Molecular Structure
Phenyl Ethers / chemistry
Phenyl Ethers / pharmacology*
Spectrometry, Mass, Electrospray Ionization

Substances

Anti-Infective Agents
Antineoplastic Agents
Hydroxybenzoates
Phenyl Ethers