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Biochem Int. 1988 Sep;17(3):471-7.

The 19 S multicatalytic "prosome" proteinase is a constitutive enzyme in HeLa cells.

Author information

1
August Krogh Institute, Universitetsparken, Copenhagen, Denmark.

Abstract

HeLa human carcinoma cells contain a high molecular mass (Mr approximately 700,000) proteinase that is identical with the ubiquitous eukaryotic 19 S cylindrical "prosome" particle. Prosomes constitute 0.6% of cell bulk protein as determined by immunochemical analysis. The prosome proteinase is not a heat shock protein, nor is it induced by cell crowding in culture or by serum deprivation. Pulse-chase experiments showed that the proteinase is relatively stable in the cells (t 1/2 approximately 5 days).

PMID:
2849441
[Indexed for MEDLINE]

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