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Cell Host Microbe. 2017 May 10;21(5):555-556. doi: 10.1016/j.chom.2017.04.014.

An Elegan(t) Screen for Drug-Microbe Interactions.

Author information

1
Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
2
Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
3
Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: robknight@ucsd.edu.

Abstract

Microbes affect drug responses, but mechanisms remain elusive. Two papers in Cell exploit C. elegans to infer anticancer drug mechanisms. Through high-throughput screens of drug-microbe-host interactions, García-González et al. (2017) and Scott et al. (2017) determine that bacterial metabolism underpins fluoropyrimidine cytotoxicity, providing a paradigm for unraveling bacterial mechanisms in drug metabolism.

PMID:
28494234
DOI:
10.1016/j.chom.2017.04.014
[Indexed for MEDLINE]
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