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Head Neck. 2017 Aug;39(8):1699-1710. doi: 10.1002/hed.24768. Epub 2017 May 11.

Comparison of risk of malignancy in a subgroup with atypia of undetermined significance/follicular lesion of undetermined significance: A meta-analysis.

Author information

1
Department of Otorhinolaryngology Head Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea.

Abstract

BACKGROUND:

As heterogeneous findings are included in the atypia of undetermined significance (AUS)/follicular lesion of undetermined significance (FLUS) category, differing risks of malignancy in subgroups have been reported in several articles.

METHODS:

We performed a meta-analysis of full-text publications written in English found in the Embase and PubMed databases.

RESULTS:

The 4-tiered subgroup proportion meta-analysis showed that the 95% confidence interval (95% CI) of the risk of malignancy in the cellular atypia group did not overlap with the other 3 subgroups and demonstrated a significant difference. Two-tiered analysis using the cytologic and architectural atypia groups showed that cytologic atypia group had a 2.64-fold increase in the risk of malignancy compared with the architectural atypia group.

CONCLUSION:

The cytologic atypia had a significantly higher risk of malignancy than the architectural atypia group, and it should be considered as a separate category.

KEYWORDS:

atypia of undetermined significance; biopsy; fine-needle; meta-analysis; neoplasm; thyroid nodule

PMID:
28493558
DOI:
10.1002/hed.24768
[Indexed for MEDLINE]

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