Genomics, transcriptomics and proteomics to elucidate the pathogenesis of rheumatoid arthritis

Rheumatol Int. 2017 Aug;37(8):1257-1265. doi: 10.1007/s00296-017-3732-3. Epub 2017 May 10.

Abstract

Rheumatoid arthritis is an autoimmune disease that affects several organs and tissues, predominantly the synovial joints. The pathogenesis of this disease is not completely understood, which maybe involved in the genomic variations, gene expression, protein translation and post-translational modifications. These system variations in genomics, transcriptomics and proteomics are dynamic in nature and their crosstalk is overwhelmingly complex, thus analyzing them separately may not be very informative. However, various '-omics' techniques developed in recent years have opened up new possibilities for clarifying disease pathways and thereby facilitating early diagnosis and specific therapies. This review examines how recent advances in the fields of genomics, transcriptomics and proteomics have contributed to our understanding of rheumatoid arthritis.

Keywords: Genomics; Omics; Proteomics; Rheumatoid arthritis; Transcriptomics.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / diagnosis
  • Arthritis, Rheumatoid / etiology*
  • Arthritis, Rheumatoid / metabolism
  • Arthritis, Rheumatoid / therapy
  • Biomarkers / metabolism
  • Early Diagnosis
  • Humans
  • Polymorphism, Genetic
  • Proteomics / methods*
  • Risk Factors
  • Transcriptome*

Substances

  • Biomarkers