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Stem Cells Int. 2017;2017:5295286. doi: 10.1155/2017/5295286. Epub 2017 Apr 12.

Wnt5a Signaling in Normal and Cancer Stem Cells.

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Medical Cancer Research Center, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Moores UCSD Cancer Center, University of California, San Diego, 3855 Health Sciences Dr., La Jolla, CA 92093, USA.


Wnt5a is involved in activating several noncanonical Wnt signaling pathways, which can inhibit or activate canonical Wnt/β-catenin signaling pathway in a receptor context-dependent manner. Wnt5a signaling is critical for regulating normal developmental processes, including stem cell self-renewal, proliferation, differentiation, migration, adhesion, and polarity. Moreover, the aberrant activation or inhibition of Wnt5a signaling is emerging as an important event in cancer progression, exerting both oncogenic and tumor suppressive effects. Recent studies show the involvement of Wnt5a signaling in regulating normal and cancer stem cell self-renewal, cancer cell proliferation, migration, and invasion. In this article, we review recent findings regarding the molecular mechanisms and roles of Wnt5a signaling in stem cells in embryogenesis and in the normal or neoplastic breast or ovary, highlighting that Wnt5a may have different effects on target cells depending on the surface receptors expressed by the target cell.

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