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J Asthma Allergy. 2017 Apr 27;10:141-151. doi: 10.2147/JAA.S113612. eCollection 2017.

Sesame allergy: current perspectives.

Author information

1
Department of Medicine, University of Alberta, Edmonton.
2
Division of Rheumatology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary.
3
Section of Allergy and Clinical Immunology, Department of Pediatrics, University of Alberta, Edmonton, AB.
4
Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.

Abstract

Sesame is an important global allergen affecting ~0.1% of the North American population. It is a major cause of anaphylaxis in the Middle East and is the third most common food allergen in Israel. We conducted a systematic review of original articles published in the last 10 years regarding the diagnosis and management of sesame allergy. Skin prick testing appears to be a useful predictor of sesame allergy in infants, although data are less consistent in older children and adults. The diagnostic capacity of serum-specific immunoglobulin E is poor, especially in studies that used oral food challenges to confirm the diagnosis. Double-blind, placebo-controlled food challenge thus remains the diagnostic gold standard for sesame allergy. The cornerstone of sesame allergy management is allergen avoidance, though accidental exposures are common and patients must be prepared to treat the consequent reactions with epinephrine. Novel diagnostic and treatment options such as component-resolved diagnostics, basophil activation testing, and oral immunotherapy are under development but are not ready for mainstream clinical application.

KEYWORDS:

component-resolved diagnostics; epinephrine autoinjector; sesame allergy; skin prick testing; specific IgE

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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