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Sci Transl Med. 2017 May 10;9(389). pii: eaan3780. doi: 10.1126/scitranslmed.aan3780.

"TrkA"cking why "no pain, no gain" is the rule for bone formation.

Author information

1
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. Email: blevi@umich.edu.

Abstract

Peripheral sensory nerves expressing TrkA innervate long bones and stimulate bone formation through the Wnt/β-catenin pathway when placed under stress.

PMID:
28490668
DOI:
10.1126/scitranslmed.aan3780
[Indexed for MEDLINE]

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