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Cold Spring Harb Perspect Med. 2018 Jun 1;8(6). pii: a029751. doi: 10.1101/cshperspect.a029751.

Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy.

Author information

1
Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294.
2
UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35205.
3
Geriatric Research, Education, and Clinical Center, Veterans' Affairs Medical Center, Birmingham, Alabama 35233.
4
Department of Physiology and Biophysics, University of California Irvine, Irvine, California 92617.

Abstract

Skeletal muscle hypertrophy is a widely sought exercise adaptation to counteract the muscle atrophy of aging and disease, or to improve athletic performance. While this desired muscle enlargement is a well-known adaptation to resistance exercise training (RT), the mechanistic underpinnings are not fully understood. The purpose of this review is thus to provide the reader with a summary of recent advances in molecular mechanisms-based on the most current literature-that are thought to promote RT-induced muscle hypertrophy. We have therefore focused this discussion on the following areas of fertile investigation: ribosomal function and biogenesis, muscle stem (satellite) cell activity, transcriptional regulation, mechanotransduction, and myokine signaling.

PMID:
28490543
PMCID:
PMC5983156
[Available on 2018-12-01]
DOI:
10.1101/cshperspect.a029751

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