Format

Send to

Choose Destination
Clin Vaccine Immunol. 2017 Jul 5;24(7). pii: e00034-17. doi: 10.1128/CVI.00034-17. Print 2017 Jul.

Waning Immunity and Microbial Vaccines-Workshop of the National Institute of Allergy and Infectious Diseases.

Author information

1
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA guxx@niaid.nih.gov.
2
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
3
Vanderbilt University, Nashville, Tennessee, USA.
4
La Jolla Institute of Allergy and Immunology, La Jolla, California, USA.
5
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
6
Precision Vaccines Program, Boston Children's Hospital, Boston, Massachusetts, USA.
7
Harvard Medical School, Boston, Massachusetts, USA.
8
University of Rochester Medical Center, Rochester, New York, USA.
9
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.

Abstract

Since the middle of the 20th century, vaccines have made a significant public health impact by controlling infectious diseases globally. Although long-term protection has been achieved with some vaccines, immunity wanes over time with others, resulting in outbreaks or epidemics of infectious diseases. Long-term protection against infectious agents that have a complex life cycle and antigenic variation remains a key challenge. Novel strategies to characterize the short- and long-term immune responses to vaccines and to induce immune responses that mimic natural infection have recently emerged. New technologies and approaches in vaccinology, such as adjuvants, delivery systems, and antigen formulations, have the potential to elicit more durable protection and fewer adverse reactions; together with in vitro systems, these technologies have the capacity to model and accelerate vaccine development. The National Institute of Allergy and Infectious Diseases (NIAID) held a workshop on 19 September 2016 that focused on waning immunity to selected vaccines (for Bordetella pertussis, Salmonella enterica serovar Typhi, Neisseria meningitidis, influenza, mumps, and malaria), with an emphasis on identifying knowledge gaps, future research needs, and how this information can inform development of more effective vaccines for infectious diseases.

KEYWORDS:

Bordetella pertussis; Neisseria meningitidis; Salmonella; adjuvants; immunity; influenza; malaria; mumps; vaccines

PMID:
28490424
PMCID:
PMC5498725
DOI:
10.1128/CVI.00034-17
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center