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Microb Pathog. 1987 Nov;3(5):319-26.

Identification of Theiler's virus infected cells in the central nervous system of the mouse during demyelinating disease.

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Départment de Virologie, UA CNRS 041157, Institut Pasteur, Paris, France.


Theiler's virus is a picornavirus responsible for a persistent, demyelinating infection of mouse central nervous system. We examined the nature of infected cells during the course of this disease using a simultaneous immunoperoxidase-in situ hybridization assay. Cell types were identified with antigenic markers and infected cells were recognized by the presence of viral RNA. We found that, depending on the animal, approximately 10% of infected cells were migroglia-macrophages, 5 to 10% were astrocytes and 25 to 40% were oligodendrocytes. Approximately half of the infected cells could not be identified.

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