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Environ Sci Technol. 2017 Jun 6;51(11):6422-6429. doi: 10.1021/acs.est.7b00801. Epub 2017 May 17.

Prenatal Nonylphenol and Bisphenol A Exposures and Inflammation Are Determinants of Oxidative/Nitrative Stress: A Taiwanese Cohort Study.

Author information

1
Institute of Environmental and Occupational Health Sciences, National Yang Ming University , Taipei, Taiwan.
2
Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston, Massachusetts United States.
3
Department of Pediatrics, Taipei City Hospital , Heping Fuyou Branch, Taipei, Taiwan.
4
Department of Obstetrics & Gynecology, Taipei City Hospital , Heping Fuyou Branch, Taipei, Taiwan.
5
Division of Pediatrics, Taipei City Hospital , Yangming Branch, Taipei, Taiwan.
6
Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University , Taipei, Taiwan.

Abstract

Prenatal exposure to nonylphenol (NP) and/or bisphenol A (BPA) has been reported to be associated with adverse birth outcomes; however, the underlying mechanisms remain unclear. The primary mechanism is endocrine disruption of the binding affinity for the estrogen receptor, but oxidative stress and inflammation might also play a contributory role. We aimed to investigate urinary NP and BPA levels in relation to biomarkers of oxidative/nitrative stress and inflammation and to explore whether changes in oxidative/nitrative stress are a function of prenatal exposure to NP/BPA and inflammation in 241 mother-fetus pairs. Third-trimester urinary biomarkers of oxidative/nitrative stress were simultaneously measured, including products of oxidatively and nitratively damaged DNA (8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NO2Gua)) as well as products of lipid peroxidation (8-iso-prostaglandin F (8-isoPF) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)). The antioxidant glutathione peroxidase (GPx) and inflammation biomarkers, including C-reactive protein (CRP) and a panel of cytokines (interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)), were analyzed in maternal and umbilical cord plasma samples. In adjusted models, we observed significant positive associations between NP exposure and 8-OHdG and 8-NO2Gua levels, between BPA and 8-isoPF levels, and between maternal CRP levels and HNE-MA levels. Additionally, BPA and TNF-α levels in cord blood were inversely associated with maternal and GPx levels in cord blood as well as maternal TNF-α levels were inversely associated with maternal GPx levels. These results support a role for exposure to NP and BPA and possibly inflammation in increasing oxidative/nitrative stress and decreasing antioxidant activity during pregnancy.

PMID:
28490175
DOI:
10.1021/acs.est.7b00801
[Indexed for MEDLINE]

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