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Food Chem. 2017 Oct 1;232:673-682. doi: 10.1016/j.foodchem.2017.04.056. Epub 2017 Apr 12.

Milk bioactive peptide database: A comprehensive database of milk protein-derived bioactive peptides and novel visualization.

Author information

1
Nutrition Program, School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, United States.
2
Nutrition Program, School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, United States. Electronic address: dave.dallas@oregonstate.edu.

Abstract

During processing and digestion, milk proteins are disassembled into peptides with an array of biological functions, including antimicrobial, angiotensin-converting enzyme inhibition, antioxidant, opioid, and immunomodulation. These functions are summarized in numerous reviews, yet information on which peptides have which functions remains scattered across hundreds of research articles. We systematically searched the literature for all instances of bioactive peptides derived from milk proteins from any mammalian source. The data were compiled into a comprehensive database, which can be used to search for specific functions, peptides, or proteins (http://mbpdb.nws.oregonstate.edu). To review this large dataset, the bioactive peptides reported in the literature were visually mapped on the parent protein sequences, providing information on sites with highest abundance of bioactive peptides.

KEYWORDS:

ACE; Casein; DPP-IV; Digestome; Peptidomics; Whey

PMID:
28490127
PMCID:
PMC5486413
DOI:
10.1016/j.foodchem.2017.04.056
[Indexed for MEDLINE]
Free PMC Article

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