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Am J Hum Biol. 2017 Sep 10;29(5). doi: 10.1002/ajhb.23016. Epub 2017 May 10.

Association between T102C 5-HT2A receptor gene polymorphism and 5-year mortality risk among Brazilian Amazon riparian elderly population.

Author information

1
Programa de Pós-Graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
2
Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
3
Programa de Pós-Graduação em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Rio Grande do Sul, Brazil.
4
Laboratory of Molecular Aspects Associated with Genetic Diseases, University of Western Santa Catarina, Unoesc, Brazil.
5
Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.
6
Laboratório de Biogenômica, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
7
Biotechnology Department, Forsyth Technical Community College, 2100 Silas Creek Parkway, Winston-Salem, North Carolina, 27103, USA.
8
BraIns-PUCRS, Brain Institute, RS, Brazil.

Abstract

OBJECTIVE:

Serotonin (5-HT) is a pleiotropic molecule that exerts several functions on brain and peripheral tissues via different receptors. The gene for the 5-HT2A receptor shows some variations, including a T102C polymorphism, that have been associated with increased risk of neuropsychiatric and vascular disorders. However, the potential impact of 5-HT2A imbalance caused by genetic variations on the human lifespan has not yet been established.

METHODS:

We performed a prospective study involving an Amazon riparian elderly free-living population in Maués City, Brazil, with a 5-year follow-up. Out of a cohort of 637 subjects selected in July, 2009, we genotyped 471 individuals, including 209 males (44.4%) and 262 females (55.6%), all averaging 72.3 ± 7.8 years of age (ranging from 60 to 100 years).

RESULTS:

The T102C-SNP genotypic frequencies were 14.0% TT, 28.0% CC, and 58.0% CT. From 80 elderly individuals who died during the period investigated, we observed significantly (P = .005) higher numbers of TT carriers (27.3%) and CC carriers (21.2%), compared to heterozygous CT carriers (12.5%). Cox-regression analysis showed that association between the T102C-SNP and elderly survival was independent of age, sex, and other health variables.

CONCLUSIONS:

Our findings strongly suggest that imbalance in 5-HT2A may cause significant disturbances that lead to an increased susceptibility to death for individuals who are over 60 years of age.

PMID:
28488759
DOI:
10.1002/ajhb.23016
[Indexed for MEDLINE]

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