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Nat Rev Mol Cell Biol. 2017 Jul;18(7):437-451. doi: 10.1038/nrm.2017.27. Epub 2017 May 10.

Alternative splicing as a regulator of development and tissue identity.

Author information

1
International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, Trieste 34149, Italy.
2
Department of Cell Biology and Physiology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
3
McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
4
Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, 111 Mason Farm Road, Chapel Hill, North Carolina 27599, USA.

Abstract

Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. It has become apparent that coordinated splicing networks regulate tissue and organ development, and that alternative splicing has important physiological functions in different developmental processes in humans.

PMID:
28488700
DOI:
10.1038/nrm.2017.27
[Indexed for MEDLINE]

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