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Diabetes Care. 2017 Jul;40(7):920-927. doi: 10.2337/dc17-0016. Epub 2017 May 9.

Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts.

Author information

1
Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway nicolai.andre.lund-blix@fhi.no.
2
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
3
Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
4
Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
5
Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
6
Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
7
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
8
Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.
9
KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
10
Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.

Abstract

OBJECTIVE:

Our aim was to study the relation between the duration of full and any breastfeeding and risk of type 1 diabetes.

RESEARCH DESIGN AND METHODS:

We included two population-based cohorts of children followed from birth (1996-2009) to 2014 (Denmark) or 2015 (Norway). We analyzed data from a total of 155,392 children participating in the Norwegian Mother and Child Cohort Study (MoBa) and the Danish National Birth Cohort (DNBC). Parents reported infant dietary practices when their child was 6 and 18 months old. The outcome was clinical type 1 diabetes, ascertained from nationwide childhood diabetes registries. Hazard ratios (HRs) were estimated using Cox regression.

RESULTS:

Type 1 diabetes was identified in 504 children during follow-up, and the incidence of type 1 diabetes per 100,000 person-years was 30.5 in the Norwegian cohort and 23.5 in the Danish cohort. Children who were never breastfed had a twofold increased risk of type 1 diabetes compared with those who were breastfed (HR 2.29 [95% CI 1.14-4.61] for no breastfeeding vs. any breastfeeding for ≥12 months). Among those who were breastfed, however, the incidence of type 1 diabetes was independent of duration of both full breastfeeding (HR per month 0.99 [95% CI 0.97-1.01]) and any breastfeeding (0.97 [0.92-1.03]).

CONCLUSIONS:

Suggestive evidence supports the contention that breastfeeding reduces the risk of type 1 diabetes. Among those who were breastfed, however, no evidence indicated that prolonging full or any breastfeeding was associated with a reduced risk of type 1 diabetes.

PMID:
28487451
PMCID:
PMC5481976
DOI:
10.2337/dc17-0016
[Indexed for MEDLINE]
Free PMC Article

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