Format

Send to

Choose Destination
Trends Biochem Sci. 2017 Jun;42(6):410-412. doi: 10.1016/j.tibs.2017.04.007. Epub 2017 May 6.

Intrinsically Disordered Proteins Adaptively Reorganize Cellular Matter During Stress.

Author information

1
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK. Electronic address: schavali@mrc-lmb.cam.ac.uk.
2
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
3
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK. Electronic address: madanm@mrc-lmb.cam.ac.uk.

Abstract

Intrinsically disordered proteins (IDPs) can protect cells from diverse stresses by forming higher order assemblies such as reversible aggregates or granules. Recently, Boothby et al. show that IDPs protect tardigrades against desiccation by forming a glass-like amorphous matrix, highlighting that material properties of disordered proteins can confer adaptation during stress.

PMID:
28487210
DOI:
10.1016/j.tibs.2017.04.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center