Format

Send to

Choose Destination
Epilepsy Res. 1988 May-Jun;2(3):215-8.

The influence of folic acid on the picrotoxin-sensitive site of the GABAa-receptor complex.

Author information

1
Dept. of Experimental Neurology, University of Nijmegen, The Netherlands.

Abstract

The site of action responsible for the convulsive effect of folic acid was investigated in vitro. Folic acid (ECmax 5 x 10(-4) M) enhances the binding of the cage convulsant [3H]t-butylbicycloorthobenzoate ([3H]TBOB) to rat brain membranes, namely to 130% of control in the absence of GABA and to over 300% of control in the presence of physiological concentrations of GABA. Analysis of the binding parameters reveals that folic acid increases the apparent number of [3H]TBOB binding sites.

PMID:
2848698
DOI:
10.1016/0920-1211(88)90058-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center