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Curr Neuropharmacol. 2018;16(1):29-36. doi: 10.2174/1570159X15666170508170412.

5-HT3 Receptors: A Potential Therapeutic Target for Epilepsy.

Author information

1
Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, China.
2
School of Life Science Northeast Normal University, Changchun, Jilin 130024, P.R. China.
3
Jinzhou Medical University, Jinzhou 121000, P.R. China.

Abstract

BACKGROUND:

Epilepsy is a syndrome of brain dysfunction caused by spontaneous, abnormal discharge. Many anti-epileptic drugs have developed in past decades. 5-HT is an important neurotransmitter in the central and peripheral nervous system of the human body which is involved in a number of physiological activities, such as sensation, movement, and behavior. 5-HT subtype have been divided into seven sub-groups from 5-HT1 to 5HT7. However, the role of 5-HT3 receptor on epilepsy is unclear. Therefore, in this article, the possible role of 5-HT3 receptor on epilepsy was systemically reviewed.

METHODS:

Data were collected from Web of Science, Medline, Pubmed, Scopus, through searching of these keywords: "5-HT3" and "epilepsy".

RESULTS:

An increasing number of studies have shown that the activation of the 5-HT3 receptor can inhibit epileptic seizures, while inhibition of the 5-HT3 receptor can promote spike waves.

CONCLUSION:

In this review, we discuss the relationship between the 5HT3 receptor and epilepsy; this review may provide a new insight for clinical application of epilepsy treatment.

KEYWORDS:

5-HT3 receptor; GABA; NMDA; Neuron; antagonists; epilepsy

PMID:
28486926
PMCID:
PMC5771379
DOI:
10.2174/1570159X15666170508170412
[Indexed for MEDLINE]
Free PMC Article

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