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J Agric Food Chem. 2017 May 31;65(21):4262-4272. doi: 10.1021/acs.jafc.7b00985. Epub 2017 May 18.

Potential Anti-inflammatory Steroidal Saponins from the Berries of Solanum nigrum L. (European Black Nightshade).

Wang Y1,2, Xiang L1,2, Yi X1,2, He X1,2.

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School of Pharmacy, Guangdong Pharmaceutical University , Guangzhou 510006, China.
Guangdong Engineering Research Center for Lead Compounds & Drug Discovery , Guangzhou 510006, China.


Solanum nigrum L. or European black nightshade (Solanum genus) is a common weed of crops and gardens. The berries and leaves of S. nigrum L. are consumed as food or vegetable in some regions and reported to possess a range of biological activities. In this study, nine new steroidal saponins, solanigrosides Y1-Y9 (1-6, 10-12), together with seven known congeners, were isolated from the berries of S. nigrum. Their potential inhibitory effects on nitric oxide (NO) and IL-6 and IL-1β production induced by lipopolysaccharide (LPS) in macrophages cell line RAW 264.7 were evaluated. Compound 1 exhibited significant inhibition on NO production with an IC50 value of 9.7 μM, and some compounds exhibited significant inhibition effects on the LPS-induced IL-6 and IL-1β production. These results suggest that the steroidal saponins from berries of S. nigrum demonstrated pronounced anti-inflammatory activity and might be explored as a healthy benefit agent.


European black nightshade; Solanum nigrum L.; anti-inflammatory activity; steroidal saponins

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