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PLoS One. 2017 May 9;12(5):e0177337. doi: 10.1371/journal.pone.0177337. eCollection 2017.

Analysis of aqueous humor concentrations of cytokines in retinoblastoma.

Cheng Y1,2,3, Zheng S4, Pan CT5, Yuan M6, Chang L7, Yao Y1,2,3, Zhao M1,2,3, Liang J1,2,3.

Author information

1
Department of Ophthalmology, People's Hospital, Peking University, Beijing, China.
2
Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
3
Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China.
4
Eye Hospital, Tradition Chinese Medicine Hospital of Yulin, Shaanxi, China.
5
Department of Ophthalmology, Peking University International Hospital, Beijing, China.
6
Department of Ophthalmology, Beijing Shunyi Airport Hospital, Beijing, China.
7
Department of Ophthalmology, Beijing Jingmei Group General Hospital, Beijing, China.

Abstract

To investigate the components of the aqueous humor (AH) in patients with retinoblastoma (RB). We collected 0.1 ml AH of 35 children with RB and 20 patients with congenital cataracts as controls. Multiplex enzyme-linked immunosorbent assays (ELISAs) and Luminex xMAP technology were used to assess 45 cytokines/chemokines, matrix metalloproteinases (MMPs), and acute-phase proteins in the identification cohort. The concentrations of IL-6, IL-7, IL-8, IFN-γ, PIGF-1, VEGF-A, β-NGF, HGF, EGF and FGF-2 were significantly higher in the AH of patients with RB than those in the control group (P<0.05). The study showed that the higher levels of IP-10, IL-6, IL-7, IL-8, IFN-γ, PIGF-1, VEGF-A, β-NGF, HGF, EGF and FGF-2 in AH may be associated with RB. Our findings may facilitate a better understanding of the molecular pathways of tumors and solid molecular targets for new strategies for therapy and the earlier diagnosis of RB.

PMID:
28486560
PMCID:
PMC5423669
DOI:
10.1371/journal.pone.0177337
[Indexed for MEDLINE]
Free PMC Article

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