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J Occup Environ Med. 2017 May;59(5):446-452. doi: 10.1097/JOM.0000000000000996.

Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study.

Author information

1
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley (Ms Lee, Dr Noth, Dr Hammond, Dr Eisen, Dr Balmes); Division of Immunology and Allergy, School of Medicine, Stanford University, Stanford (Dr Nadeau); Department of Biochemistry and Biophysics (Dr Lin); Division of Occupational and Environmental Medicine, School of Medicine (Dr Balmes), University of California, San Francisco, San Francisco, California.

Abstract

OBJECTIVE:

The main objective of this pilot study was to gather preliminary information about how telomere length (TL) varies in relation to exposure to polycyclic aromatic hydrocarbons (PAHs) in children living in a highly polluted city.

METHODS:

We conducted a cross-sectional study of children living in Fresno, California (n = 14). Subjects with and without asthma were selected based on their annual average PAH level in the 12-months prior to their blood draw. We measured relative telomere length from peripheral blood mononuclear cells (PBMC).

RESULTS:

We found an inverse linear relationship between average PAH level and TL (R = 0.69), as well as between age and TL (R = 0.21). Asthmatics had shorter mean telomere length than non-asthmatics (TLasthmatic = 1.13, TLnon-asthmatic = 1.29).

CONCLUSIONS:

These preliminary findings suggest that exposure to ambient PAH may play a role in telomere shortening.Become familiar with previous evidence suggesting that telomere length may be a biomarker of air pollution-induced cytotoxicity.Summarize the new findings on the association between polycyclic aromatic hydrocarbon (PAH) exposure and telomere length in adolescents, including those with asthma.Discuss the implications for recommendations and policies to mitigate the health and respiratory effects of traffic-related air pollution.

PMID:
28486341
PMCID:
PMC5424623
DOI:
10.1097/JOM.0000000000000996
[Indexed for MEDLINE]
Free PMC Article

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