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Curr Opin Virol. 2017 Apr;23:95-101. doi: 10.1016/j.coviro.2017.04.002. Epub 2017 May 6.

Recent advances in human flavivirus vaccines.

Author information

1
Department of Medicine, Imperial College London, W12 0NN London, UK.
2
Department of Medicine, Imperial College London, W12 0NN London, UK; Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
3
Department of Medicine, Imperial College London, W12 0NN London, UK. Electronic address: g.screaton@imperial.ac.uk.

Abstract

Dengue (DENV), West Nile (WNV) and Zika (ZIKV) viruses are mosquito-transmitted flaviviruses that cause thousands of human deaths and millions of illnesses each year. In the last decades, epidemic outbreaks of all three flaviviruses emerged and caused a major health and economical problem in many parts of the world. The increasing and expanding burden of flaviviruses has highlighted the need for effective human vaccines against all three viruses. This review provides an overview of the recent progress in DENV, WNV and ZIKV vaccines development with specific focus on candidates in human clinical development.

PMID:
28486135
DOI:
10.1016/j.coviro.2017.04.002
[Indexed for MEDLINE]
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