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Cancer Cell. 2017 May 8;31(5):609-611. doi: 10.1016/j.ccell.2017.04.008.

Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer.

Author information

1
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
2
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: gutmannd@wustl.edu.

Abstract

In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain developmental programs can be hijacked in cancer.

PMID:
28486100
DOI:
10.1016/j.ccell.2017.04.008
[Indexed for MEDLINE]
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