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J Peripher Nerv Syst. 2017 Sep;22(3):162-171. doi: 10.1111/jns.12219.

Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy.

Author information

1
Department of Neurology and Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Abstract

Distal axon degeneration seen in many peripheral neuropathies is likely to share common molecular mechanisms with Wallerian degeneration. Although several studies in mouse models of peripheral neuropathy showed prevention of axon degeneration in the slow Wallerian degeneration (Wlds) mouse, the role of a recently identified player in Wallerian degeneration, Sarm1, has not been explored extensively. In this study, we show that mice lacking the Sarm1 gene are resistant to distal axonal degeneration in a model of chemotherapy induced peripheral neuropathy caused by paclitaxel and a model of high fat diet induced putative metabolic neuropathy. This study extends the role of Sarm1 to axon degeneration seen in peripheral neuropathies and identifies it as a likely target for therapeutic development.

KEYWORDS:

NMNAT2; Sarm1; Wallerian degeneration; Wlds; diabetic neuropathy; distal axon degeneration; paclitaxel; peripheral neuropathy

PMID:
28485482
PMCID:
PMC5585053
DOI:
10.1111/jns.12219
[Indexed for MEDLINE]
Free PMC Article

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