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Asian J Psychiatr. 2017 Apr;26:99-103. doi: 10.1016/j.ajp.2017.01.026. Epub 2017 Jan 25.

Cytokines, cortisol and IGF-1 in first episode psychosis and ultra high risk males. Evidence for TNF-α, IFN-γ, ΤNF-β, IL-4 deviation.

Author information

1
The University of Queensland, Rural Clinical School, School of Medicine, 152, West St., Toowoomba, QLD 4350, Australia; 424 General Military Hospital of Thessaloniki, Psychiatric Department, Thessaloniki Ring Road, 56429 Efkarpia, Thessaloniki, Greece. Electronic address: epkarani@yahoo.com.
2
International Business Machines Corporation, New Orchard Road, Armonk, New York 10504 USA.
3
424 General Military Hospital of Thessaloniki, Psychiatric Department, Thessaloniki Ring Road, 56429 Efkarpia, Thessaloniki, Greece.
4
2nd Psychiatric Department, Aristotle University of Thessaloniki, 196 Lagkadast, Stavroupoli 564 29, Thessaloniki, Greece.

Abstract

The aim of the study was to determine circulating cytokines, cortisol and Insulin-like Growth Factor (IGF)-1, known for their involvement in inflammation, in male patients with First Episode Psychosis (FEP) and subjects at Ultra High Risk (UHR) for Psychosis. The FEP group presented increased pro-inflammatory cytokines (TNF-α, IFN-γ, ΤNF-β) as well as increased anti-inflammatory cytokine (IL-4) compared with Healthy Controls (HC). The UHR group showed increased IL-4 against HC. In contrast, none of the groups did show deviation from normality in either cortisol or IGF-1 levels. These preliminary findings support the cytokines' role in the inflammatory hypothesis in psychosis.

KEYWORDS:

Cortisol; Cytokines; First episode psychosis; IGF-1; Ultra high risk

PMID:
28483103
DOI:
10.1016/j.ajp.2017.01.026
[Indexed for MEDLINE]

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