Format

Send to

Choose Destination
Leuk Lymphoma. 2017 Nov;58(11):2624-2632. doi: 10.1080/10428194.2017.1312376. Epub 2017 May 9.

Diagnosis of secondary peripheral neurolymphomatosis: a multi-center experience.

Author information

1
a Department of Internal Medicine , Seoul National University College of Medicine, Seoul National University Hospital , Seoul , Korea.
2
b Department of Internal Medicine , Seoul Metropolitan Government Seoul National University Boramae Medical Center , Seoul , Korea.
3
c Department of Internal Medicine , Seoul National University Bundang Hospital , Seongnam , Korea.
4
d Department of Pathology, College of Medicine , Seoul National University , Seoul , Korea.
5
e Department of Pathology , Seoul National University Bundang Hospital , Seongnam , Korea.
6
f Department of Nuclear Medicine , Seoul National University Bundang Hospital , Seongnam , Korea.
7
g Department of Nuclear Medicine , Seoul National University, College of Medicine , Seoul , Korea.

Abstract

Here, we describe our experience with secondary neurolymphomatosis (NL) in non-Hodgkin lymphoma patients, with the emphasis on the diagnosis process. A retrospective chart review of 12 patients from 3 tertiary academic centers between January 2005 and December 2015 was conducted. Secondary NL was diagnosed within a median interval of 10 months (range 5-41 months) after initial diagnosis of NHL. Painful neuropathy was present in 66.7%, but the diagnosis of NL was delayed in nine out of 12 patients (75.0%) by median of 2 months. Diagnostic modalities included CSF analysis performed in nine patients (75.0%), electrodiagnostic studies in seven (58.3%), radiologic studies in all, and nerve biopsy in two (16.7%). The diagnostic yield was 100.0% (15/15) for FDG-PET/CT and 75.0% (9/12) for MRI. Our experience emphasizes the importance of clinical suspicion of NL in patients with previous history of NHL and selection of diagnostic modality with the greatest clinical utility.

KEYWORDS:

FDG-PET/CT; MRI; Neurolymphomatosis; non-Hodgkin lymphoma

PMID:
28482727
DOI:
10.1080/10428194.2017.1312376
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center