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Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:301-312. doi: 10.1016/j.msec.2017.02.167. Epub 2017 Mar 11.

Zn-Li alloy after extrusion and drawing: Structural, mechanical characterization, and biodegradation in abdominal aorta of rat.

Author information

1
Department of Materials Science and Engineering, Michigan Technological University, Houghton, MI, USA.
2
Institut für Werkstoffkunde (Materials Science), Leibniz Universität Hannover, Garbsen, Germany.
3
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA.
4
Department of Materials Science and Engineering, Michigan Technological University, Houghton, MI, USA. Electronic address: jwdrelic@mtu.edu.

Abstract

Zinc shows great promise as a bio-degradable metal. Our early in vivo investigations implanting pure zinc wires into the abdominal aorta of Sprague-Dawley rats revealed that metallic zinc does not promote restenotic responses and may suppress the activities of inflammatory and smooth muscle cells. However, the low tensile strength of zinc remains a major concern. A cast billet of the Zn-Li alloy was produced in a vacuum induction caster under argon atmosphere, followed by a wire drawing process. Two phases of the binary alloy identified by x-ray diffraction include the zinc phase and intermetallic LiZn4 phase. Mechanical testing proved that incorporating 0.1wt% of Li into Zn increased its ultimate tensile strength from 116±13MPa (pure Zn) to 274±61MPa while the ductility was held at 17±7%. Implantation of 10mm Zn-Li wire segments into abdominal aorta of rats revealed an excellent biocompatibility of this material in the arterial environment. The biodegradation rate for Zn-Li was found to be about 0.008mm/yr and 0.045mm/yr at 2 and 12months, respectively.

PMID:
28482531
PMCID:
PMC5459357
DOI:
10.1016/j.msec.2017.02.167
[Indexed for MEDLINE]
Free PMC Article

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